ABSTRACT
Objective: To analyze the clinical application effect and satisfaction of a self designed multifunctional wire arranging plate in the nursing care of operation rooms. Methods: 108 patients who had received abdominal operation were divided into observation group (54 cases) and control group (54 cases) according to random method. And risk nursing was applied in both of two groups, while a multifunctional wire arranging plate was given additionally to the observation group. The psychological comfort level, quality of care and satisfaction between the two groups were compared. Results: The postoperative SAS and SDS scores of both groups were better than that of preoperative scores, and the postoperative SAS and SDS of observation group were significantly higher than that of control group (t=9.2126, t=13.3934, P<0.01). And the scores of basic nursing, aseptic condition, nursing record, goods management and safety management of the observation group were (96.23±3.24), (95.56±7.23), (93.36±6.32), (93.65±6.45) and (95.69±2.65), respectively. And all of them were significantly better than that of the control group (t=12.1185, t=13.8281, t=8.7427, t=11.0142, t=10.0133, P<0.01). The difference of total satisfaction rate of nursing between the observation group (94.44%) and control group (79.63%) was significant (x2=5.2523, P<0.05). Conclusion: The application of a multifunctional wire arranging plate for nursing care in operation rooms can effectively enhance the psychological comfort level of patients, and promote the quality improvement of nursing, and enhance nursing satisfaction of patients.
ABSTRACT
<p><b>OBJECTIVE</b>To construct angiogenesis-specific RGD10-NGR9 dual-targeting superparamagnetic iron oxide nanoparticles, and to evaluate its magnetic resonamce imaging (MRI) features in nude mice and potential diagnostic value in tumor MRI.</p><p><b>METHODS</b>Dual-targeting peptides RGD10-NGR9 were designed and synthesized. Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles were synthesized by chemical co-precipitation method and the surface was modified to be hydrophilic by coating with dextran. The dual-targeting peptides RGD10-NGR9 were conjugated to USPIO. Cell binding affinity and up-taking ability of the dual-targeting USPIO nanoparticles to integrin ανβ3-APN positive cells were subsequently tested by Prussian blue staining and phenanthroline colorimetry in vitro. The RGD10-NGR9 conjugated with USPIO was injected intravenously into xenograft mice, which were scanned by MRI at predetermined time points. The MRI and contrast-to-noise ratio (CNR) values were calculated to evaluate the ability of dual-targeting USPIO as a potential contrast agent in nude mice.</p><p><b>RESULTS</b>P-CLN-Dextran-USPIO nanoparticles with stable physical properties were successfully constructed. The average diameter of Fe3O4 nanoparticles was 8-10 nm, that of Dextran-USPIO was about 20 nm and P-CLN-Dextran-USPIO had an average diameter about 30 nm. The in vitro studies showed a better specificity of dual-targeting USPIO nanoparticles on proliferating human umbilical vein endothelia cells (HUVEC). In vivo, RGD10-NGR9-USPIO showed a significantly reduced contrast in signal intensity and 2.83-times increased the CNR in the tumor MRI in xenograft mice.</p><p><b>CONCLUSION</b>This novel synthesized RGD10-NGR9 dual-targeting USPIO is with better specific affinity in vitro and in vivo, and might be used as a molecular contrast agent for tumor angiogenesis MRI.</p>